Table: q1_q4_2023_prescription_drug_wac_increases_5_year_history , manufacturer_name like O*

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manufacturer_name	ndc_number	effective_date	history_effective_date	wac_increase_amount	wac_amount
Optinose US, Inc.	71143037501	2023-01-01 00:00:00	2018-08-01 00:00:00	21.25	446.25
Optinose US, Inc.	71143037501	2023-01-01 00:00:00	2019-01-01 00:00:00	21.87	468.12
Optinose US, Inc.	71143037501	2023-01-01 00:00:00	2019-07-01 00:00:00	22.47	490.59
Optinose US, Inc.	71143037501	2023-01-01 00:00:00	2020-01-01 00:00:00	24.04	514.63
Optinose US, Inc.	71143037501	2023-01-01 00:00:00	2021-01-01 00:00:00	28.34	542.97
Optinose US, Inc.	71143037501	2023-01-01 00:00:00	2022-01-01 00:00:00	25.57	568.54
Optinose US, Inc.	71143037501	2023-01-01 00:00:00	2023-01-01 00:00:00	28.43	596.97
Organon	78206015001	2023-10-02 00:00:00	2023-10-02 00:00:00	53.74	170.0
Otsuka America Pharmaceutical, Inc.	59148001871	2023-01-15 00:00:00	2018-07-01 00:00:00	72.94	1624.81
Otsuka America Pharmaceutical, Inc.	59148001871	2023-01-15 00:00:00	2019-04-01 00:00:00	81.24	1706.05
Otsuka America Pharmaceutical, Inc.	59148001871	2023-01-15 00:00:00	2021-01-15 00:00:00	85.3	1791.35
Otsuka America Pharmaceutical, Inc.	59148001871	2023-01-15 00:00:00	2022-01-15 00:00:00	123.6	1914.95
Otsuka America Pharmaceutical, Inc.	59148001871	2023-01-15 00:00:00	2023-01-15 00:00:00	124.47	2039.42
Otsuka America Pharmaceutical, Inc.	59148001971	2023-01-15 00:00:00	2018-07-01 00:00:00	97.25	2166.41
Otsuka America Pharmaceutical, Inc.	59148001971	2023-01-15 00:00:00	2019-04-01 00:00:00	108.32	2274.73
Otsuka America Pharmaceutical, Inc.	59148001971	2023-01-15 00:00:00	2021-01-15 00:00:00	113.74	2388.47
Otsuka America Pharmaceutical, Inc.	59148001971	2023-01-15 00:00:00	2022-01-15 00:00:00	164.8	2553.27
Otsuka America Pharmaceutical, Inc.	59148001971	2023-01-15 00:00:00	2023-01-15 00:00:00	165.96	2719.23
Otsuka America Pharmaceutical, Inc.	59148003513	2023-01-15 00:00:00	2018-04-01 00:00:00	99.9	1109.42
Otsuka America Pharmaceutical, Inc.	59148003513	2023-01-15 00:00:00	2019-04-01 00:00:00	55.47	1164.89
Otsuka America Pharmaceutical, Inc.	59148003513	2023-01-15 00:00:00	2021-01-15 00:00:00	81.54	1246.43
Otsuka America Pharmaceutical, Inc.	59148003513	2023-01-15 00:00:00	2022-01-15 00:00:00	86.0	1332.43
Otsuka America Pharmaceutical, Inc.	59148003513	2023-01-15 00:00:00	2023-01-15 00:00:00	86.61	1419.04
Otsuka America Pharmaceutical, Inc.	59148003613	2023-01-15 00:00:00	2018-04-01 00:00:00	99.9	1109.42
Otsuka America Pharmaceutical, Inc.	59148003613	2023-01-15 00:00:00	2019-04-01 00:00:00	55.47	1164.89
Otsuka America Pharmaceutical, Inc.	59148003613	2023-01-15 00:00:00	2021-01-15 00:00:00	81.54	1246.43
Otsuka America Pharmaceutical, Inc.	59148003613	2023-01-15 00:00:00	2022-01-15 00:00:00	86.0	1332.43
Otsuka America Pharmaceutical, Inc.	59148003613	2023-01-15 00:00:00	2023-01-15 00:00:00	86.61	1419.04
Otsuka America Pharmaceutical, Inc.	59148003713	2023-01-15 00:00:00	2018-04-01 00:00:00	99.9	1109.42
Otsuka America Pharmaceutical, Inc.	59148003713	2023-01-15 00:00:00	2019-04-01 00:00:00	55.47	1164.89
Otsuka America Pharmaceutical, Inc.	59148003713	2023-01-15 00:00:00	2021-01-15 00:00:00	81.54	1246.43
Otsuka America Pharmaceutical, Inc.	59148003713	2023-01-15 00:00:00	2022-01-15 00:00:00	86.0	1332.43
Otsuka America Pharmaceutical, Inc.	59148003713	2023-01-15 00:00:00	2023-01-15 00:00:00	86.61	1419.04
Otsuka America Pharmaceutical, Inc.	59148003813	2023-01-15 00:00:00	2018-04-01 00:00:00	99.9	1109.42
Otsuka America Pharmaceutical, Inc.	59148003813	2023-01-15 00:00:00	2019-04-01 00:00:00	55.47	1164.89
Otsuka America Pharmaceutical, Inc.	59148003813	2023-01-15 00:00:00	2021-01-15 00:00:00	81.54	1246.43
Otsuka America Pharmaceutical, Inc.	59148003813	2023-01-15 00:00:00	2022-01-15 00:00:00	86.0	1332.43
Otsuka America Pharmaceutical, Inc.	59148003813	2023-01-15 00:00:00	2023-01-15 00:00:00	86.61	1419.04
Otsuka America Pharmaceutical, Inc.	59148003913	2023-01-15 00:00:00	2018-04-01 00:00:00	99.9	1109.42
Otsuka America Pharmaceutical, Inc.	59148003913	2023-01-15 00:00:00	2019-04-01 00:00:00	55.47	1164.89
Otsuka America Pharmaceutical, Inc.	59148003913	2023-01-15 00:00:00	2021-01-15 00:00:00	81.54	1246.43
Otsuka America Pharmaceutical, Inc.	59148003913	2023-01-15 00:00:00	2022-01-15 00:00:00	86.0	1332.43
Otsuka America Pharmaceutical, Inc.	59148003913	2023-01-15 00:00:00	2023-01-15 00:00:00	86.61	1419.04
Otsuka America Pharmaceutical, Inc.	59148004013	2023-01-15 00:00:00	2018-04-01 00:00:00	99.9	1109.42
Otsuka America Pharmaceutical, Inc.	59148004013	2023-01-15 00:00:00	2019-04-01 00:00:00	55.47	1164.89
Otsuka America Pharmaceutical, Inc.	59148004013	2023-01-15 00:00:00	2021-01-15 00:00:00	81.54	1246.43
Otsuka America Pharmaceutical, Inc.	59148004013	2023-01-15 00:00:00	2022-01-15 00:00:00	86.0	1332.43
Otsuka America Pharmaceutical, Inc.	59148004013	2023-01-15 00:00:00	2023-01-15 00:00:00	86.61	1419.04
Otsuka America Pharmaceutical, Inc.	59148004580	2023-01-15 00:00:00	2018-07-01 00:00:00	72.94	1624.81
Otsuka America Pharmaceutical, Inc.	59148004580	2023-01-15 00:00:00	2019-04-01 00:00:00	81.24	1706.05
Otsuka America Pharmaceutical, Inc.	59148004580	2023-01-15 00:00:00	2021-01-15 00:00:00	85.3	1791.35
Otsuka America Pharmaceutical, Inc.	59148004580	2023-01-15 00:00:00	2022-01-15 00:00:00	123.6	1914.95
Otsuka America Pharmaceutical, Inc.	59148004580	2023-01-15 00:00:00	2023-01-15 00:00:00	124.47	2039.42
Otsuka America Pharmaceutical, Inc.	59148007280	2023-01-15 00:00:00	2018-07-01 00:00:00	97.25	2166.41
Otsuka America Pharmaceutical, Inc.	59148007280	2023-01-15 00:00:00	2019-04-01 00:00:00	108.32	2274.73
Otsuka America Pharmaceutical, Inc.	59148007280	2023-01-15 00:00:00	2021-01-15 00:00:00	113.74	2388.47
Otsuka America Pharmaceutical, Inc.	59148007280	2023-01-15 00:00:00	2022-01-15 00:00:00	164.8	2553.27
Otsuka America Pharmaceutical, Inc.	59148007280	2023-01-15 00:00:00	2023-01-15 00:00:00	165.96	2719.23
Otsuka America Pharmaceutical, Inc.	59148007928	2023-01-15 00:00:00	2021-01-15 00:00:00	1051.74	16076.56
Otsuka America Pharmaceutical, Inc.	59148007928	2023-01-15 00:00:00	2022-01-15 00:00:00	1109.28	17185.84
Otsuka America Pharmaceutical, Inc.	59148007928	2023-01-15 00:00:00	2023-01-15 00:00:00	1117.08	18302.92
Otsuka America Pharmaceutical, Inc.	59148008028	2023-01-15 00:00:00	2021-01-15 00:00:00	1051.74	16076.56
Otsuka America Pharmaceutical, Inc.	59148008028	2023-01-15 00:00:00	2022-01-15 00:00:00	1109.28	17185.84
Otsuka America Pharmaceutical, Inc.	59148008028	2023-01-15 00:00:00	2023-01-15 00:00:00	1117.08	18302.92
Otsuka America Pharmaceutical, Inc.	59148008213	2023-01-15 00:00:00	2019-07-15 00:00:00	330.1	7665.72
Otsuka America Pharmaceutical, Inc.	59148008213	2023-01-15 00:00:00	2020-01-15 00:00:00	383.29	8049.01
Otsuka America Pharmaceutical, Inc.	59148008213	2023-01-15 00:00:00	2021-01-15 00:00:00	563.43	8612.44
Otsuka America Pharmaceutical, Inc.	59148008213	2023-01-15 00:00:00	2022-01-15 00:00:00	594.26	9206.7
Otsuka America Pharmaceutical, Inc.	59148008213	2023-01-15 00:00:00	2023-01-15 00:00:00	598.44	9805.14
Otsuka America Pharmaceutical, Inc.	59148008313	2023-01-15 00:00:00	2019-07-15 00:00:00	330.1	7665.72
Otsuka America Pharmaceutical, Inc.	59148008313	2023-01-15 00:00:00	2020-01-15 00:00:00	383.29	8049.01
Otsuka America Pharmaceutical, Inc.	59148008313	2023-01-15 00:00:00	2021-01-15 00:00:00	563.43	8612.44
Otsuka America Pharmaceutical, Inc.	59148008313	2023-01-15 00:00:00	2022-01-15 00:00:00	594.26	9206.7
Otsuka America Pharmaceutical, Inc.	59148008313	2023-01-15 00:00:00	2023-01-15 00:00:00	598.44	9805.14
Otsuka America Pharmaceutical, Inc.	59148008728	2023-01-15 00:00:00	2019-01-15 00:00:00	652.06	13693.16
Otsuka America Pharmaceutical, Inc.	59148008728	2023-01-15 00:00:00	2019-07-15 00:00:00	616.19	14309.35
Otsuka America Pharmaceutical, Inc.	59148008728	2023-01-15 00:00:00	2020-01-15 00:00:00	715.47	15024.82
Otsuka America Pharmaceutical, Inc.	59148008728	2023-01-15 00:00:00	2021-01-15 00:00:00	1051.74	16076.56
Otsuka America Pharmaceutical, Inc.	59148008728	2023-01-15 00:00:00	2022-01-15 00:00:00	1109.28	17185.84
Otsuka America Pharmaceutical, Inc.	59148008728	2023-01-15 00:00:00	2023-01-15 00:00:00	1117.08	18302.92
Otsuka America Pharmaceutical, Inc.	59148008828	2023-01-15 00:00:00	2019-01-15 00:00:00	652.06	13693.16
Otsuka America Pharmaceutical, Inc.	59148008828	2023-01-15 00:00:00	2019-07-15 00:00:00	616.19	14309.35
Otsuka America Pharmaceutical, Inc.	59148008828	2023-01-15 00:00:00	2020-01-15 00:00:00	715.47	15024.82
Otsuka America Pharmaceutical, Inc.	59148008828	2023-01-15 00:00:00	2021-01-15 00:00:00	1051.74	16076.56
Otsuka America Pharmaceutical, Inc.	59148008828	2023-01-15 00:00:00	2022-01-15 00:00:00	1109.28	17185.84
Otsuka America Pharmaceutical, Inc.	59148008828	2023-01-15 00:00:00	2023-01-15 00:00:00	1117.08	18302.92
Otsuka America Pharmaceutical, Inc.	59148008928	2023-01-15 00:00:00	2019-01-15 00:00:00	652.06	13693.16
Otsuka America Pharmaceutical, Inc.	59148008928	2023-01-15 00:00:00	2019-07-15 00:00:00	616.19	14309.35
Otsuka America Pharmaceutical, Inc.	59148008928	2023-01-15 00:00:00	2020-01-15 00:00:00	715.47	15024.82
Otsuka America Pharmaceutical, Inc.	59148008928	2023-01-15 00:00:00	2021-01-15 00:00:00	1051.74	16076.56
Otsuka America Pharmaceutical, Inc.	59148008928	2023-01-15 00:00:00	2022-01-15 00:00:00	1109.28	17185.84
Otsuka America Pharmaceutical, Inc.	59148008928	2023-01-15 00:00:00	2023-01-15 00:00:00	1117.08	18302.92
Otter Pharmaceuticals LLC	10094020501	2023-01-01 00:00:00	2020-01-01 00:00:00	0.65	13.65
Otter Pharmaceuticals LLC	10094020501	2023-01-01 00:00:00	2021-01-01 00:00:00	0.7	14.35
Otter Pharmaceuticals LLC	10094020501	2023-01-01 00:00:00	2022-01-03 00:00:00	0.79	15.14
Otter Pharmaceuticals LLC	10094020501	2023-01-01 00:00:00	2023-01-01 00:00:00	0.74	15.88
Otter Pharmaceuticals LLC	10094020560	2023-01-01 00:00:00	2020-01-01 00:00:00	39.0	819.0
Otter Pharmaceuticals LLC	10094020560	2023-01-01 00:00:00	2021-01-01 00:00:00	42.0	861.0
Otter Pharmaceuticals LLC	10094020560	2023-01-01 00:00:00	2022-01-03 00:00:00	47.4	908.4
Otter Pharmaceuticals LLC	10094020560	2023-01-01 00:00:00	2023-01-01 00:00:00	44.4	952.8
Otter Pharmaceuticals LLC	10094021001	2023-01-01 00:00:00	2020-01-01 00:00:00	1.3	27.3
Otter Pharmaceuticals LLC	10094021001	2023-01-01 00:00:00	2021-01-01 00:00:00	1.4	28.7
Otter Pharmaceuticals LLC	10094021001	2023-01-01 00:00:00	2022-01-03 00:00:00	1.58	30.28
Otter Pharmaceuticals LLC	10094021001	2023-01-01 00:00:00	2023-01-01 00:00:00	1.48	31.76
Otter Pharmaceuticals LLC	10094021060	2023-01-01 00:00:00	2020-01-01 00:00:00	78.0	1638.0
Otter Pharmaceuticals LLC	10094021060	2023-01-01 00:00:00	2021-01-01 00:00:00	84.0	1722.0
Otter Pharmaceuticals LLC	10094021060	2023-01-01 00:00:00	2022-01-03 00:00:00	94.8	1816.8
Otter Pharmaceuticals LLC	10094021060	2023-01-01 00:00:00	2023-01-01 00:00:00	88.8	1905.6
Otter Pharmaceuticals LLC	10094022001	2023-01-01 00:00:00	2020-01-01 00:00:00	2.6	54.6
Otter Pharmaceuticals LLC	10094022001	2023-01-01 00:00:00	2021-01-01 00:00:00	2.8	57.4
Otter Pharmaceuticals LLC	10094022001	2023-01-01 00:00:00	2022-01-03 00:00:00	3.16	60.56
Otter Pharmaceuticals LLC	10094022001	2023-01-01 00:00:00	2023-01-01 00:00:00	2.97	63.53
Otter Pharmaceuticals LLC	10094022060	2023-01-01 00:00:00	2020-01-01 00:00:00	156.0	3276.0
Otter Pharmaceuticals LLC	10094022060	2023-01-01 00:00:00	2021-01-01 00:00:00	168.0	3444.0
Otter Pharmaceuticals LLC	10094022060	2023-01-01 00:00:00	2022-01-03 00:00:00	189.6	3633.6
Otter Pharmaceuticals LLC	10094022060	2023-01-01 00:00:00	2023-01-01 00:00:00	178.2	3811.8
OWP Pharmaceuticals, Inc.	69102013710	2023-02-01 00:00:00	2019-10-11 00:00:00	42.0	577.0
OWP Pharmaceuticals, Inc.	69102013710	2023-02-01 00:00:00	2020-08-01 00:00:00	40.0	617.0
OWP Pharmaceuticals, Inc.	69102013710	2023-02-01 00:00:00	2021-03-01 00:00:00	31.0	648.0
OWP Pharmaceuticals, Inc.	69102013710	2023-02-01 00:00:00	2022-02-01 00:00:00	32.0	680.0
OWP Pharmaceuticals, Inc.	69102013710	2023-02-01 00:00:00	2023-02-01 00:00:00	55.0	735.0
OWP Pharmaceuticals, Inc.	69102030001	2023-02-01 00:00:00	2019-10-11 00:00:00	42.0	577.0
OWP Pharmaceuticals, Inc.	69102030001	2023-02-01 00:00:00	2020-08-01 00:00:00	40.0	617.0
OWP Pharmaceuticals, Inc.	69102030001	2023-02-01 00:00:00	2021-03-01 00:00:00	31.0	648.0
OWP Pharmaceuticals, Inc.	69102030001	2023-02-01 00:00:00	2022-02-01 00:00:00	32.0	680.0
OWP Pharmaceuticals, Inc.	69102030001	2023-02-01 00:00:00	2023-02-01 00:00:00	55.0	735.0
OWP Pharmaceuticals, Inc.	69102030601	2023-02-01 00:00:00	2021-03-01 00:00:00	21.0	446.0
OWP Pharmaceuticals, Inc.	69102030601	2023-02-01 00:00:00	2022-02-01 00:00:00	22.0	468.0
OWP Pharmaceuticals, Inc.	69102030601	2023-02-01 00:00:00	2023-02-01 00:00:00	37.0	505.0
OWP Pharmaceuticals, Inc.	69102031201	2023-02-01 00:00:00	2019-10-11 00:00:00	88.0	1188.0
OWP Pharmaceuticals, Inc.	69102031201	2023-02-01 00:00:00	2021-03-01 00:00:00	59.0	1247.0
OWP Pharmaceuticals, Inc.	69102031201	2023-02-01 00:00:00	2022-02-01 00:00:00	62.0	1309.0
OWP Pharmaceuticals, Inc.	69102031201	2023-02-01 00:00:00	2023-02-01 00:00:00	105.0	1414.0
OWP Pharmaceuticals, Inc.	69102035911	2023-02-01 00:00:00	2019-10-11 00:00:00	88.0	1188.0
OWP Pharmaceuticals, Inc.	69102035911	2023-02-01 00:00:00	2021-03-01 00:00:00	59.0	1247.0
OWP Pharmaceuticals, Inc.	69102035911	2023-02-01 00:00:00	2022-02-01 00:00:00	62.0	1309.0
OWP Pharmaceuticals, Inc.	69102035911	2023-02-01 00:00:00	2023-02-01 00:00:00	105.0	1414.0
OWP Pharmaceuticals, Inc.	69102063909	2023-02-01 00:00:00	2021-03-01 00:00:00	21.0	446.0
OWP Pharmaceuticals, Inc.	69102063909	2023-02-01 00:00:00	2022-02-01 00:00:00	22.0	468.0
OWP Pharmaceuticals, Inc.	69102063909	2023-02-01 00:00:00	2023-02-01 00:00:00	37.0	505.0